Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4728722 | 0.91 | ADORA2A (0.53) | KITEGFRERBB2TLR8MAOB | |
| SCHEMBL4727883 | 0.86 | CYP3A4 (0.49) | KITEGFRERBB2TLR8MAOB | |
| SCHEMBL4730192 | 0.82 | PDE10A (0.55) | — | |
| SCHEMBL4727924 | 0.81 | MAPT (0.49) | KITALDH1A1LMNATLR8MAPT | |
| SCHEMBL28872954 | 0.78 | ADORA2A (0.66) | NPSR1ALDH1A1LMNAHTTEGFR | |
| SCHEMBL4725258 | 0.77 | KDM1A (0.57) | KITLMNAHTTEGFRMAPK1 | |
| SCHEMBL6824579 | 0.77 | PRMT5 (0.50) | NPSR1ALDH1A1LMNAHTTEGFR | |
| SCHEMBL7982589 | 0.77 | CSF1R (0.57) | KITEGFRERBB2MAOBMAPT | |
| SCHEMBL4725570 | 0.76 | IP6K1 (0.50) | EGFRERBB2PRMT5CYP3A4FLT3 | |
| SCHEMBL5465811 | 0.76 | MEN1 (0.55) | KITLMNAEGFRERBB2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | disclosed |