Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.57 |
| ▸ | FLT4 | P35916 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 3/20 | 0.50 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.48 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.48 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.47 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | KIF5B | P33176 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8204598 | 0.84 | CSF1R (0.47) | CSF1RPDGFRBFLT4FLT3TRPA1 | |
| SCHEMBL4359665 | 0.83 | CSF1R (0.81) | CSF1RPDGFRBFLT4FLT3KIT | |
| SCHEMBL7962833 | 0.83 | TRPA1 (0.52) | CSF1RPDGFRBFLT4FLT3TRPA1 | |
| SCHEMBL15607578 | 0.81 | PDGFRB (0.77) | CSF1RPDGFRBFLT4FLT3KIT | |
| SCHEMBL19968424 | 0.79 | CYP3A4 (0.57) | PDGFRBKITPDGFRAMAOB | |
| SCHEMBL8810873 | 0.79 | PDGFRB (0.68) | CSF1RPDGFRBFLT4FLT3KIT | |
| SCHEMBL4023315 | 0.79 | PDGFRB (0.75) | CSF1RPDGFRBFLT4FLT3KIT | |
| SCHEMBL30406755 | 0.77 | CSF1R (0.68) | CSF1RPDGFRBFLT4FLT3KIT | |
| SCHEMBL4466873 | 0.77 | CSF1R (0.68) | CSF1RPDGFRBFLT4FLT3KIT | |
| SCHEMBL4728679 | 0.77 | KIT (0.56) | CSF1RPDGFRBFLT4FLT3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294532-B1 | TREATMENT OF A NUMBER OF DISEASE STATES INCLUDING CANCER AND RHEUMATOID ARTHRITIS. | ZENECA LIMITED (GB) | 2001-09-25 | — | — | US | disclosed |
| US-6071921-A | Chemical compounds | ZENECA LIMITED (GB) | 2000-06-06 | — | — | US | disclosed |