Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CIT | O14578 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | BUB1 | O43683 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4731787 | 0.90 | JAK2 (0.45) | JAK2PDGFRBFLT3TBK1IKBKB | |
| SCHEMBL4730280 | 0.88 | JAK2 (0.43) | TERTJAK2PDGFRBFLT3TBK1 | |
| SCHEMBL4730678 | 0.81 | PIK3CB (0.44) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4572916 | 0.81 | PIK3CB (0.44) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4574510 | 0.81 | PIK3CB (0.44) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3987968 | 0.79 | JAK2 (0.51) | JAK2PDGFRBFLT3TBK1IKBKB | |
| SCHEMBL4729907 | 0.79 | JAK2 (0.51) | JAK2PDGFRBFLT3TBK1IKBKB | |
| SCHEMBL4469166 | 0.78 | PIK3CA (0.41) | TERTJAK2PDGFRBFLT3TBK1 | |
| SCHEMBL4728335 | 0.77 | JAK2 (0.48) | JAK2PDGFRBFLT3TBK1IKBKB | |
| SCHEMBL4727905 | 0.77 | ATR (0.49) | PIK3CAMTORCYP3A4PIK3CGATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008032077-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | disclosed |