Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 1.00 |
| ▸ | RAB9A | P51151 | 8/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17265005 | 0.79 | RAB9A (0.64) | NPC1RAB9ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL7112860 | 0.75 | RAB9A (0.60) | NPC1RAB9ASMN1; SMN2MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL29899398 | 0.74 | RAB9A (0.58) | NPC1RAB9ASMN1; SMN2MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL29899408 | 0.74 | RAB9A (0.58) | NPC1RAB9ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL9570481 | 0.74 | RAB9A (0.61) | NPC1RAB9ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL103116 | 0.74 | RAB9A (0.61) | NPC1RAB9ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL260197 | 0.73 | PDE10A (1.00) | NPC1RAB9ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL14736747 | 0.73 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL15361824 | 0.72 | PDE10A (0.66) | NPC1RAB9ASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL259357 | 0.72 | PDE10A (0.68) | NPC1RAB9ASMN1; SMN2MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008029152-A2 | TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2008-03-13 | — | — | WO | disclosed |