Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17323627 | 0.83 | EPHX2 (0.58) | EPHX2POLBSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL12437007 | 0.83 | EPHX2 (0.58) | EPHX2SMN1; SMN2TP53 | |
| SCHEMBL5217099 | 0.79 | HTR4 (0.48) | EPHX2SMN1; SMN2ALDH1A1LMNAGAA | |
| SCHEMBL30884651 | 0.79 | EPHX2 (0.61) | EPHX2ALDH1A1LMNAGAA | |
| SCHEMBL30606194 | 0.79 | EPHX2 (0.66) | EPHX2SMN1; SMN2ALDH1A1NPSR1LMNA | |
| SCHEMBL3377958 | 0.79 | TP53 (0.61) | POLBSMN1; SMN2ALDH1A1NPSR1GAA | |
| SCHEMBL29851226 | 0.78 | POLB (0.51) | POLBSMN1; SMN2ALDH1A1NPSR1LMNA | |
| SCHEMBL23343181 | 0.77 | EPHX2 (0.52) | EPHX2POLBSMN1; SMN2LMNATP53 | |
| SCHEMBL21596763 | 0.77 | EPHX2 (0.46) | EPHX2TP53 | |
| SCHEMBL22749233 | 0.77 | SMN1; SMN2 (0.60) | POLBSMN1; SMN2ALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008045564-A2 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS ANTAGONISTS OF THE CHEMOKINE CCR2 RECEPTOR | EPIX DELAWARE, INC. (US) | 2008-04-17 | — | — | WO | claimed |
| CN-114901653-B | Novel amide derivatives useful as diacylglycerol acyltransferase 2 inhibitors and uses thereof | 株式会社LG化学 | 2024-11-22 | — | — | CN | disclosed |
| CN-114901653-A | Novel amide derivatives useful as diacylglycerol acyltransferase 2 inhibitors and uses thereof | 株式会社LG化学 | 2022-08-12 | — | — | CN | disclosed |