Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 7/20 | 0.52 |
| ▸ | EGFR | P00533 | 6/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725127 | 0.90 | CSF1R (0.51) | CSF1REGFRPDGFRBPDGFRAPDE10A | |
| SCHEMBL4728977 | 0.82 | PDE10A (0.47) | EGFRPDE10ACYP1A2ENPP1KDM1A | |
| SCHEMBL4728469 | 0.82 | PDE10A (0.47) | EGFRPDE10ACYP1A2ENPP1KDM1A | |
| SCHEMBL4725040 | 0.79 | PDE10A (0.44) | EGFRPDE10ACYP1A2ENPP1KDM1A | |
| SCHEMBL4726586 | 0.79 | PDE10A (0.44) | EGFRPDE10ACYP1A2ENPP1KDM1A | |
| SCHEMBL8261880 | 0.79 | CSF1R (0.64) | CSF1REGFRPDGFRBPDGFRAENPP1 | |
| SCHEMBL4725054 | 0.78 | ACHE (0.55) | PDE10AKDM1A | |
| SCHEMBL4725230 | 0.78 | ACHE (0.55) | PDE10AKDM1A | |
| SCHEMBL4779965 | 0.78 | ACHE (0.54) | PDGFRBPDE10AKDM1A | |
| Hydrochloric Acid SCHEMBL8518306 | 0.78 | CSF1R (0.65) | CSF1REGFRPDGFRBPDGFRAENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | claimed |