Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | CCR2 | P41597 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780748 | 0.80 | CCR2 (0.41) | SLC6A4CYP3A4CYP2D6CCR2 | |
| SCHEMBL1691743 | 0.69 | SLC6A2 (0.52) | PRMT5WDR77SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4727699 | 0.68 | CETP (0.39) | CYP3A4CCR2KMT2A | |
| SCHEMBL4782016 | 0.68 | CCR2 (0.38) | SLC6A4CYP2D6CCR2 | |
| SCHEMBL4732645 | 0.68 | CCR2 (0.42) | SLC6A2SLC6A4CCR2 | |
| SCHEMBL4731707 | 0.68 | TACR1 (0.41) | SLC6A2SLC6A4SLC6A3CCR2 | |
| SCHEMBL4729023 | 0.66 | PRMT5 (0.46) | PRMT5WDR77CCR2KMT2ACCR5 | |
| SCHEMBL415119 | 0.65 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3CYP2D6KCNH2 | |
| SCHEMBL5995859 | 0.65 | SLC6A2 (0.70) | PRMT5WDR77SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7491671 | 0.65 | SLC6A4 (0.53) | PRMT5WDR77SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008045564-A2 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS ANTAGONISTS OF THE CHEMOKINE CCR2 RECEPTOR | EPIX DELAWARE, INC. (US) | 2008-04-17 | — | — | WO | disclosed |