Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 5/20 | 0.41 |
| ▸ | TACR1 | P25103 | 11/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782016 | 0.87 | CCR2 (0.38) | CCR2TACR1TSHRSLC6A4CYP2D6 | |
| SCHEMBL4732645 | 0.87 | CCR2 (0.42) | CCR2TACR1SLC6A4 | |
| SCHEMBL4731707 | 0.84 | TACR1 (0.41) | CCR2TACR1SLC6A4 | |
| SCHEMBL4729719 | 0.84 | CCR2 (0.37) | CCR2TACR1TSHRSLC6A4CYP3A4 | |
| SCHEMBL4727699 | 0.82 | CETP (0.39) | CCR2TACR1CYP3A4 | |
| SCHEMBL4728688 | 0.82 | CCR2 (0.36) | CCR2TACR1SLC6A4 | |
| SCHEMBL4732208 | 0.82 | CCR2 (0.36) | CCR2TACR1TSHRSLC6A4CYP3A4 | |
| SCHEMBL4731339 | 0.82 | CCR2 (0.40) | CCR2TACR1SLC6A4CYP2D6 | |
| SCHEMBL4729022 | 0.80 | PRMT5 (0.40) | CCR2SLC6A4CYP3A4CYP2D6 | |
| SCHEMBL4731859 | 0.80 | GPBAR1 (0.39) | CCR2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008045564-A2 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS ANTAGONISTS OF THE CHEMOKINE CCR2 RECEPTOR | EPIX DELAWARE, INC. (US) | 2008-04-17 | — | — | WO | claimed |