Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22261640 | 0.87 | NPC1 (0.46) | NPC1KMT2AMEN1CYP1A2ALDH1A1 | |
| SCHEMBL9098730 | 0.78 | METAP1 (0.40) | NPC1KMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL7399114 | 0.76 | KMT2A (0.38) | NPC1KMT2AMEN1CYP1A2ALDH1A1 | |
| SCHEMBL1726822 | 0.75 | MAPT (0.37) | NPC1KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL2106418 | 0.75 | NPSR1 (0.42) | NPC1KMT2AALDH1A1POLBL3MBTL1 | |
| SCHEMBL18090576 | 0.74 | POLB (0.46) | NPC1ALDH1A1POLBLMNAMAPT | |
| SCHEMBL13992658 | 0.74 | MAPT (0.36) | NPC1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL4309544 | 0.74 | KMT2A (0.36) | NPC1KMT2AMEN1CYP1A2ALDH1A1 | |
| SCHEMBL31531423 | 0.74 | MAPT (0.40) | NPC1KMT2ACYP1A2KDM4EPOLB | |
| SCHEMBL2106155 | 0.73 | NPC1 (0.66) | NPC1KMT2AMEN1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008043791-A2 | THIOPHENE DERIVATIVES FOR TREATING HEPATITIS C | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |
| WO-2008043791-A2 | THIOPHENE DERIVATIVES FOR TREATING HEPATITIS C | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |