Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | EDNRA | P25101 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18090574 | 0.86 | LMNA (0.55) | LMNAEDNRA | |
| SCHEMBL22261640 | 0.76 | NPC1 (0.46) | POLBLMNANPC1MAPTALDH1A1 | |
| SCHEMBL12319426 | 0.75 | EDNRA (0.52) | POLBLMNATP53THRBEDNRA | |
| SCHEMBL11471141 | 0.75 | EDNRA (0.52) | POLBLMNATP53THRBEDNRA | |
| SCHEMBL4729037 | 0.74 | NPC1 (0.47) | POLBLMNANPC1MAPTALDH1A1 | |
| SCHEMBL3822222 | 0.74 | TSHR (0.53) | POLBLMNATP53THRBEDNRA | |
| SCHEMBL388034 | 0.73 | MAPT (0.55) | POLBLMNATP53THRBEDNRA | |
| SCHEMBL31607236 | 0.73 | EDNRA (0.51) | POLBLMNATP53THRBEDNRA | |
| SCHEMBL4358291 | 0.73 | CA1 (0.51) | POLBLMNATP53THRBEDNRA | |
| SCHEMBL11469582 | 0.72 | EDNRA (0.56) | POLBLMNATP53THRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9440954-B2 | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-09-13 | — | — | US | disclosed |
| US-9440954-B2 | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-09-13 | — | — | US | disclosed |
| CN-104334542-A | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors | CHIESI FARMA SPA | 2015-02-04 | — | — | CN | disclosed |