Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 17/20 | 0.47 |
| ▸ | BRAF | P15056 | 14/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727147 | 0.92 | MAPK14 (0.48) | RAF1BRAFMAPK14EGLN1 | |
| SCHEMBL4727468 | 0.88 | MAPK14 (0.47) | RAF1BRAFMAPK14EGLN1 | |
| SCHEMBL4727464 | 0.87 | RAF1 (0.48) | RAF1BRAF | |
| SCHEMBL4728995 | 0.86 | RAF1 (0.53) | RAF1BRAF | |
| SCHEMBL4726220 | 0.84 | RAF1 (0.41) | RAF1BRAFMAPK14 | |
| SCHEMBL4725070 | 0.84 | TEK (0.46) | RAF1BRAF | |
| SCHEMBL4730967 | 0.83 | RAF1 (0.44) | RAF1BRAFMAPK14EGLN1 | |
| SCHEMBL4725881 | 0.82 | RAF1 (0.42) | RAF1BRAF | |
| SCHEMBL4725920 | 0.82 | EGLN1 (0.48) | MAPK14EGLN1 | |
| SCHEMBL4725917 | 0.82 | RAF1 (0.44) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |