Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.44 |
| ▸ | RAF1 | P04049 | 6/20 | 0.42 |
| ▸ | BRAF | P15056 | 6/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4726220 | 0.92 | RAF1 (0.41) | MAPK14RAF1BRAFTRPV1TEK | |
| SCHEMBL4729206 | 0.92 | RAF1 (0.47) | MAPK14EGLN1RAF1BRAF | |
| SCHEMBL4727842 | 0.86 | RAF1 (0.45) | RAF1BRAFTEK | |
| SCHEMBL4725881 | 0.85 | RAF1 (0.42) | RAF1BRAFTEK | |
| SCHEMBL4725070 | 0.85 | TEK (0.46) | RAF1BRAFTRPV1TEK | |
| SCHEMBL4726247 | 0.84 | RAF1 (0.43) | RAF1BRAFTEK | |
| SCHEMBL4728099 | 0.83 | RAF1 (0.41) | MAPK14EGLN1RAF1BRAF | |
| SCHEMBL4726798 | 0.83 | RAF1 (0.42) | RAF1BRAFTRPV1TEK | |
| SCHEMBL4727320 | 0.83 | CNR2 (0.42) | MAPK14NPC1RAB9ARAF1BRAF | |
| SCHEMBL4725920 | 0.82 | EGLN1 (0.48) | MAPK14EGLN1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |