Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 3/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4728308 | 0.91 | EGLN1 (0.48) | EGLN1NAMPTTAAR1LMNAALDH1A1 | |
| SCHEMBL4728367 | 0.89 | MAPK14 (0.50) | CYP2C9MAPK14TAAR1LMNAALDH1A1 | |
| SCHEMBL4727468 | 0.88 | MAPK14 (0.47) | EGLN1MAPK14NAMPT | |
| SCHEMBL4728099 | 0.85 | RAF1 (0.41) | EGLN1MAPK14 | |
| SCHEMBL4725917 | 0.84 | RAF1 (0.44) | — | |
| SCHEMBL4726798 | 0.83 | RAF1 (0.42) | — | |
| SCHEMBL4729070 | 0.83 | IKBKB (0.43) | EGLN1MAPK14ALDH1A1KMT2AMEN1 | |
| SCHEMBL4729206 | 0.82 | RAF1 (0.47) | EGLN1MAPK14 | |
| SCHEMBL4727147 | 0.82 | MAPK14 (0.48) | EGLN1MAPK14KMT2AMEN1 | |
| SCHEMBL4729551 | 0.82 | RAF1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |