Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 13/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780145 | 0.90 | MEN1 (0.64) | MEN1KMT2AMAPTLMNAGAA | |
| SCHEMBL31328307 | 0.90 | MEN1 (0.64) | MEN1KMT2AMAPTLMNAGAA | |
| SCHEMBL8220387 | 0.90 | MEN1 (0.67) | MEN1KMT2AMAPTLMNAGAA | |
| SCHEMBL16266056 | 0.83 | MEN1 (0.67) | MEN1KMT2AMAPTLMNAGAA | |
| SCHEMBL4726198 | 0.83 | SIRT1 (0.55) | MEN1KMT2AMAPTLMNAGAA | |
| SCHEMBL4779722 | 0.82 | SIRT1 (0.62) | MEN1KMT2AMAPTLMNAALOX15 | |
| SCHEMBL4725046 | 0.81 | MEN1 (1.00) | MEN1KMT2AMAPTLMNAGAA | |
| SCHEMBL31612407 | 0.81 | MEN1 (1.00) | MEN1KMT2AMAPTLMNAGAA | |
| SCHEMBL34464423 | 0.81 | MEN1 (0.60) | MEN1KMT2AMAPTLMNAGAA | |
| SCHEMBL31328320 | 0.81 | MEN1 (0.60) | MEN1KMT2AMAPTLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008019825-A1 | USE OF TRICYCLIC INDOLE DERIVATIVES FOR THE TREATMENT OF MUSCULAR DISEASES | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2008-02-21 | — | — | WO | disclosed |
| WO-2008019825-A1 | USE OF TRICYCLIC INDOLE DERIVATIVES FOR THE TREATMENT OF MUSCULAR DISEASES | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2008-02-21 | — | — | WO | disclosed |