Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.61 |
| ▸ | RAF1 | P04049 | 13/20 | 0.60 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.60 |
| ▸ | LYN | P07948 | 1/20 | 0.60 |
| ▸ | BRAF | P15056 | 12/20 | 0.57 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781398 | 0.99 | RAF1 (0.62) | MAPK14RAF1HSPB1LYNBRAF | |
| SCHEMBL4782204 | 0.93 | RAF1 (0.69) | MAPK14RAF1HSPB1BRAFMAPK13 | |
| SCHEMBL20008242 | 0.80 | RAF1 (0.84) | RAF1BRAF | |
| SCHEMBL4782241 | 0.79 | RAF1 (0.44) | MAPK14RAF1HSPB1LYNBRAF | |
| SCHEMBL4726861 | 0.78 | TEK (0.47) | RAF1BRAF | |
| SCHEMBL4729438 | 0.78 | MEN1 (0.54) | RAF1BRAF | |
| SCHEMBL4729086 | 0.78 | CYP2C9 (0.47) | RAF1BRAF | |
| SCHEMBL4728328 | 0.77 | RAF1 (0.54) | MAPK14RAF1BRAF | |
| SCHEMBL4725914 | 0.77 | RAF1 (0.41) | RAF1BRAF | |
| SCHEMBL4784220 | 0.76 | MAPK14 (0.42) | MAPK14RAF1HSPB1LYNBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |