Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 4/20 | 0.42 |
| ▸ | RAF1 | P04049 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4726861 | 0.89 | TEK (0.47) | MEN1KMT2ATRPV1BRAFRAF1 | |
| SCHEMBL4729086 | 0.88 | CYP2C9 (0.47) | TRPV1BRAFRAF1 | |
| SCHEMBL4784220 | 0.86 | MAPK14 (0.42) | BRAFRAF1 | |
| SCHEMBL4729210 | 0.85 | TRPV1 (0.42) | EPHX2TRPV1BRAFRAF1HDAC3 | |
| SCHEMBL4730164 | 0.85 | MAPK14 (0.53) | BRAFRAF1 | |
| SCHEMBL4729549 | 0.85 | BTK (0.40) | TRPV1BRAFRAF1ALDH1A1MAPT | |
| SCHEMBL4729484 | 0.85 | TRPV1 (0.41) | EPHX2TRPV1BRAFRAF1HDAC3 | |
| SCHEMBL4729212 | 0.85 | TRPV1 (0.41) | TRPV1BRAFRAF1HDAC3HDAC6 | |
| SCHEMBL4729370 | 0.84 | ABL1 (0.46) | BRAFRAF1ALDH1A1MAPT | |
| SCHEMBL4781066 | 0.83 | MAPK14 (0.55) | RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |