Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.64 |
| ▸ | KDM1A | O60341 | 2/20 | 0.61 |
| ▸ | ACHE | P22303 | 4/20 | 0.55 |
| ▸ | BACE1 | P56817 | 4/20 | 0.55 |
| ▸ | GAK | O14976 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725230 | 0.92 | ACHE (0.55) | PDE10AKDM1AACHEBACE1AURKA | |
| SCHEMBL4725054 | 0.92 | ACHE (0.55) | PDE10AKDM1AACHEBACE1AURKA | |
| SCHEMBL4779965 | 0.91 | ACHE (0.54) | PDE10AKDM1AACHEBACE1AURKA | |
| SCHEMBL4725590 | 0.81 | PDE3A (0.75) | PDE10A | |
| SCHEMBL4728977 | 0.78 | PDE10A (0.47) | PDE10AKDM1ALMNACYP1A2MAPK1 | |
| SCHEMBL4728469 | 0.78 | PDE10A (0.47) | PDE10AKDM1ALMNACYP1A2MAPK1 | |
| SCHEMBL4725127 | 0.78 | CSF1R (0.51) | PDE10ALMNACYP1A2CYP3A4TSHR | |
| SCHEMBL4727792 | 0.78 | PDE3A (0.73) | PDE10A | |
| SCHEMBL4728985 | 0.76 | CSF1R (0.52) | PDE10AKDM1ACYP1A2 | |
| SCHEMBL22946970 | 0.76 | ACHE (0.72) | PDE10AKDM1AACHEBACE1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | claimed |
| WO-2008020302-A2 | HETEROAROMATIC QUINOLINE-BASED COMPOUNDS AS PHOSPHODIESTERASE (PDE) INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-02-21 | — | — | WO | disclosed |