Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | PRNP | P04156 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4778018 | 0.92 | SMN1; SMN2 (0.54) | SMN1; SMN2HTTNPC1MEN1KMT2A | |
| SCHEMBL2434458 | 0.82 | SMN1; SMN2 (0.65) | SMN1; SMN2HTTNPC1MEN1KMT2A | |
| SCHEMBL101584 | 0.79 | SMN1; SMN2 (0.49) | SMN1; SMN2HTTNPC1MEN1KMT2A | |
| SCHEMBL1961677 | 0.77 | SMN1; SMN2 (0.53) | SMN1; SMN2HTTNPC1MEN1KMT2A | |
| SCHEMBL4776364 | 0.77 | HPGDS (0.36) | SMN1; SMN2HTTKMT2AHPGDKDM4E | |
| SCHEMBL4725298 | 0.75 | MEN1 (0.52) | SMN1; SMN2HTTNPC1MEN1KMT2A | |
| SCHEMBL15118765 | 0.75 | SMN1; SMN2 (0.46) | SMN1; SMN2HTTNPC1MEN1KMT2A | |
| SCHEMBL23287054 | 0.72 | HDAC1 (0.45) | SMN1; SMN2NPC1ALDH1A1MAPTGAA | |
| SCHEMBL23286901 | 0.72 | HDAC1 (0.45) | SMN1; SMN2NPC1ALDH1A1MAPTGAA | |
| SCHEMBL23286899 | 0.72 | HDAC1 (0.45) | SMN1; SMN2NPC1ALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008043791-A2 | THIOPHENE DERIVATIVES FOR TREATING HEPATITIS C | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |
| WO-2008043791-A2 | THIOPHENE DERIVATIVES FOR TREATING HEPATITIS C | SMITHKLINE BEECHAM CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |