Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 7/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | WNT3 | P56703 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4735361 | 0.89 | CCR8 (0.39) | SFRP1KMT2AMEN1CCR8 | |
| SCHEMBL4730981 | 0.89 | SFRP1 (0.46) | SFRP1KMT2AMEN1WNT3HTR1A | |
| SCHEMBL4730139 | 0.87 | SFRP1 (0.45) | SFRP1KMT2AMEN1WNT3HTR1A | |
| SCHEMBL4919374 | 0.84 | HTT (0.36) | KMT2AMEN1 | |
| SCHEMBL4801590 | 0.83 | HTT (0.38) | KMT2AMEN1 | |
| SCHEMBL4735483 | 0.82 | BRD4 (0.41) | SFRP1KMT2AMEN1WNT3CCR8 | |
| SCHEMBL4732186 | 0.82 | HTT (0.36) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL4732586 | 0.82 | HTT (0.38) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL4735363 | 0.80 | CCR8 (0.39) | SFRP1KMT2AMEN1CCR8 | |
| SCHEMBL4730986 | 0.80 | SFRP1 (0.46) | SFRP1KMT2AMEN1WNT3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |