Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 8/20 | 0.35 |
| ▸ | BRD2 | P25440 | 3/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732586 | 0.99 | HTT (0.38) | HTTTP53BRD4BRD2BRD3 | |
| SCHEMBL4735483 | 0.89 | BRD4 (0.41) | HTTTP53BRD4BRD2BRD3 | |
| SCHEMBL4919374 | 0.89 | HTT (0.36) | HTTTP53BRD4BRD2BRD3 | |
| SCHEMBL4801590 | 0.88 | HTT (0.38) | HTTTP53BRD4BRD2BRD3 | |
| SCHEMBL4736205 | 0.87 | HTT (0.35) | HTTTP53BRD4BRD2BRD3 | |
| SCHEMBL4730155 | 0.86 | CNR2 (0.39) | HTTLMNAGAATSHR | |
| SCHEMBL4732243 | 0.85 | CNR2 (0.39) | HTTLMNAGAATSHRALDH1A1 | |
| SCHEMBL4732359 | 0.85 | BRD4 (0.36) | HTTTP53BRD4BRD2BRD3 | |
| SCHEMBL4730903 | 0.82 | SFRP1 (0.44) | MEN1KMT2AALDH1A1 | |
| SCHEMBL4795053 | 0.82 | ALDH1A1 (0.38) | HTTBRD4BRD2BRD3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |