Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.36 |
| ▸ | MT-CO1 | P00395 | 1/20 | 0.35 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | HTR1F | P30939 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615623 | 0.78 | ALDH1A1 (0.53) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL1442910 | 0.75 | PRMT1 (0.45) | P4HTMMT-CO1MT-CO2EDNRAOPRM1 | |
| Hydrochloric Acid SCHEMBL17893734 | 0.73 | PRMT1 (0.44) | P4HTMMT-CO1MT-CO2EDNRAOPRM1 | |
| SCHEMBL22583342 | 0.73 | P4HTM (0.40) | P4HTMHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL17394904 | 0.72 | HDAC3 (0.30) | HDAC3HDAC1HDAC6 | |
| SCHEMBL14061768 | 0.72 | GRM5 (0.55) | — | |
| SCHEMBL22396435 | 0.72 | P4HTM (0.63) | P4HTMALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL30449388 | 0.68 | P4HTM (0.59) | P4HTMALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL15440496 | 0.68 | P4HTM (0.42) | P4HTMALDH1A1APLNRNPC1GAA | |
| SCHEMBL17447442 | 0.68 | P4HTM (0.42) | P4HTMALDH1A1APLNRNPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054284-A1 | A NEW PROCESS FOR THE PRODUCTION OF 5-FLUORO-PYRIDINE-2- CARBONITRILE AND 5-FLUORO-N-HYDROXY-PYRIDINE-2- CARBOXAMIDINE. | ASTRAZENECA AB (SE) | 2008-05-08 | — | — | WO | claimed |
| US-20250026743-A1 | HETEROARYL-LINKED ANALOGS AS MGLU5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME | VANDERBILT UNIVERSITY | 2025-01-23 | — | — | US | disclosed |
| CN-118251390-A | Heteroaryl linked analogs as MGLU5 negative allosteric modulators and methods of making and using the same | 范德比尔特大学 | 2024-06-25 | — | — | CN | disclosed |
| US-20130210804-A1 | TRICYCLIC MGLUR5 RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. | 2013-08-15 | — | — | US | disclosed |
| WO-2008054284-A1 | A NEW PROCESS FOR THE PRODUCTION OF 5-FLUORO-PYRIDINE-2- CARBONITRILE AND 5-FLUORO-N-HYDROXY-PYRIDINE-2- CARBOXAMIDINE. | ASTRAZENECA AB (SE) | 2008-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250026743-A1 | HETEROARYL-LINKED ANALOGS AS MGLU5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME | GRM5, GRIK5, GRM2 | P4HTM 3235/4885MT-CO1 2747/4885MT-CO2 2832/4885 |
| US-20130210804-A1 | TRICYCLIC MGLUR5 RECEPTOR MODULATORS | GRM5, GRM1, GRM2 | P4HTM 2136/4885MT-CO1 1581/4885MT-CO2 1874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.