Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 13/20 | 0.58 |
| ▸ | IL1B | P01584 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 5/20 | 0.49 |
| ▸ | CASP7 | P55210 | 2/20 | 0.49 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.49 |
| ▸ | CASP9 | P55211 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27634060 | 1.00 | CASP1 (0.58) | CASP1IL1BCASP3CASP7CASP8 | |
| SCHEMBL473203 | 1.00 | CASP1 (0.58) | CASP1IL1BCASP3CASP7CASP8 | |
| SCHEMBL473090 | 0.90 | CASP1 (0.55) | CASP1IL1BCASP3CASP7CASP8 | |
| SCHEMBL473088 | 0.90 | CASP1 (0.55) | CASP1IL1BCASP3CASP7CASP8 | |
| SCHEMBL473091 | 0.90 | CASP1 (0.55) | CASP1IL1BCASP3CASP7CASP8 | |
| SCHEMBL473238 | 0.89 | CASP1 (0.62) | CASP1CASP3CASP7CASP8 | |
| SCHEMBL473237 | 0.89 | CASP1 (0.62) | CASP1CASP3CASP7CASP8 | |
| SCHEMBL27654106 | 0.89 | CASP1 (0.62) | CASP1CASP3CASP7CASP8 | |
| SCHEMBL14664263 | 0.88 | CASP1 (0.52) | CASP1CASP3CASP7CASP8 | |
| SCHEMBL473222 | 0.87 | CASP1 (0.65) | CASP1IL1BCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2412707-A2 | 3-[2-(3-Amino-2-oxo-2H-pyridin-1-yl)-acetylamino]-4-oxo-pentanoic acid derivatives and their use as caspase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-02-01 | — | — | EP | disclosed |
| US-7960415-B2 | Caspase inhibitors and uses thereof | Vertex Pharmaceutical Incoporated (US) | 2011-06-14 | — | — | US | disclosed |
| CN-101775012-A | Aspartic acid specific cysteine proteinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPO | 2010-07-14 | — | — | CN | disclosed |
| CN-1812972-B | Caspase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPO | 2010-04-28 | — | — | CN | disclosed |
| US-20090093416-A1 | CASPASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED | 2009-04-09 | — | — | US | disclosed |
| CN-1812972-A | Caspase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPO (US) | 2006-08-02 | — | — | CN | disclosed |
| US-20040242494-A1 | Caspase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242494-A1 | Caspase inhibitors and uses thereof | CASP1, CASP5, CASP3 | CASP1 1/4885IL1B 110/4885CASP3 3/4885 |
| US-20090093416-A1 | CASPASE INHIBITORS AND USES THEREOF | CASP1, CASP5, CASP3 | CASP1 1/4885IL1B 137/4885CASP3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.