Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 11/20 | 0.51 |
| ▸ | TACR1 | P25103 | 2/20 | 0.50 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13222832 | 0.89 | CYP2D6 (0.48) | CCR2TACR1CCR5CYP3A4ALDH1A1 | |
| SCHEMBL3036649 | 0.86 | CCR2 (0.49) | CCR2TACR1CCR5CYP3A4ALDH1A1 | |
| SCHEMBL3040315 | 0.85 | TACR1 (0.55) | CCR2TACR1CCR5CYP3A4ALDH1A1 | |
| SCHEMBL13243692 | 0.83 | CCR2 (0.43) | CCR2TACR1CCR5CYP3A4ALDH1A1 | |
| SCHEMBL3030595 | 0.81 | CCR2 (0.48) | CCR2TACR1CCR5CYP3A4ALDH1A1 | |
| SCHEMBL14221691 | 0.81 | TACR1 (0.65) | CCR2TACR1CYP3A4ALDH1A1TSHR | |
| SCHEMBL3997558 | 0.81 | CCR2 (0.51) | CCR2TACR1KCNH2 | |
| Ammonia Solution, Strong SCHEMBL3036646 | 0.80 | TACR1 (0.64) | CCR2TACR1CYP3A4ALDH1A1TSHR | |
| Trifluoroacetic Acid SCHEMBL3030594 | 0.80 | TACR1 (0.64) | CCR2TACR1CYP3A4ALDH1A1CYP2D6 | |
| SCHEMBL3042038 | 0.77 | CCR2 (0.55) | CCR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008045564-A2 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS ANTAGONISTS OF THE CHEMOKINE CCR2 RECEPTOR | EPIX DELAWARE, INC. (US) | 2008-04-17 | — | — | WO | disclosed |