Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 16/20 | 0.57 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | CCR8 | P51685 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | WNT3 | P56703 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732351 | 0.88 | SFRP1 (0.45) | SFRP1USP2CYP1A2SMN1; SMN2MAPK1 | |
| SCHEMBL4735525 | 0.86 | SFRP1 (0.61) | SFRP1WNT3 | |
| SCHEMBL4733644 | 0.85 | SFRP1 (0.60) | SFRP1WNT3 | |
| SCHEMBL4735911 | 0.84 | SFRP1 (0.54) | SFRP1WNT3 | |
| SCHEMBL4732571 | 0.83 | SFRP1 (0.58) | SFRP1WNT3 | |
| SCHEMBL4733575 | 0.83 | SFRP1 (0.71) | SFRP1WNT3 | |
| SCHEMBL4732947 | 0.82 | SFRP1 (0.53) | SFRP1WNT3 | |
| SCHEMBL4785270 | 0.82 | SFRP1 (0.60) | SFRP1WNT3 | |
| SCHEMBL4732834 | 0.81 | SFRP1 (0.59) | SFRP1WNT3 | |
| SCHEMBL4734823 | 0.81 | SFRP1 (0.52) | SFRP1WNT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |