Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.44 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.44 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.44 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12470962 | 0.85 | MTOR (0.43) | MTORRICTORRPTORMAPKAP1MLST8 | |
| SCHEMBL281990 | 0.83 | L3MBTL1 (0.36) | MTORRICTORRPTORMAPKAP1MLST8 | |
| SCHEMBL3326333 | 0.81 | SCN9A (0.35) | MTORRICTORRPTORMAPKAP1MLST8 | |
| SCHEMBL1612096 | 0.81 | KMT2A (0.63) | MTORRICTORRPTORMAPKAP1MLST8 | |
| SCHEMBL4727528 | 0.79 | KMT2A (0.44) | KMT2AMEN1LMNAMAPTNPSR1 | |
| SCHEMBL2303883 | 0.78 | PDE7A (0.37) | SCN9AKMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL282095 | 0.75 | KMT2A (0.46) | KMT2AMEN1LMNAMAPTNPSR1 | |
| SCHEMBL1612150 | 0.75 | SCN9A (0.56) | SCN9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL15314983 | 0.75 | SCN9A (0.53) | SCN9ALMNAMAPTGAAMAPK1 | |
| SCHEMBL1611952 | 0.73 | KMT2A (0.63) | MTORRICTORRPTORMAPKAP1MLST8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008046087-A2 | SPIRO COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2008-04-17 | — | — | WO | disclosed |