Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.39 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.39 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.39 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1612096 | 0.92 | KMT2A (0.63) | KMT2AMEN1POLBCASP6GAA | |
| SCHEMBL17244108 | 0.83 | KMT2A (0.45) | KMT2AMEN1POLBGAAMAPK1 | |
| SCHEMBL384666 | 0.75 | KMT2A (0.43) | KMT2AMEN1GAAMAPK1MAPT | |
| SCHEMBL281811 | 0.74 | KMT2A (0.42) | KMT2AMEN1MTORRICTORRPTOR | |
| SCHEMBL281520 | 0.73 | KMT2A (0.69) | KMT2AMEN1POLBCASP6GAA | |
| SCHEMBL4597267 | 0.73 | POLB (0.55) | KMT2AMEN1POLBCASP6MTOR | |
| SCHEMBL4732189 | 0.73 | MTOR (0.44) | KMT2AMEN1POLBGAAMAPK1 | |
| SCHEMBL15314988 | 0.73 | TSHR (0.47) | GAALMNAMAPTALDH1A1SCN9A | |
| SCHEMBL2306814 | 0.72 | KMT2A (0.40) | KMT2AMEN1LMNAMTORRICTOR | |
| SCHEMBL281976 | 0.72 | KMT2A (0.40) | KMT2AMEN1MTORRICTORRPTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9695185-B2 | Synthetic methods for spiro-oxindole compounds | XENON PHARMACEUTICALS INC. (CA) | 2017-07-04 | — | — | US | disclosed |
| US-9695185-B2 | Synthetic methods for spiro-oxindole compounds | XENON PHARMACEUTICALS INC. (CA) | 2017-07-04 | — | — | US | disclosed |
| US-9695185-B2 | Synthetic methods for spiro-oxindole compounds | XENON PHARMACEUTICALS INC. (CA) | 2017-07-04 | — | — | US | disclosed |
| US-20160326184-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2016-11-10 | — | — | US | disclosed |
| US-20160326184-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2016-11-10 | — | — | US | disclosed |
| US-20160326184-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2016-11-10 | — | — | US | disclosed |
| US-9260446-B2 | Synthetic methods for spiro-oxindole compounds | XENON PHARMACEUTICALS INC. (CA) | 2016-02-16 | — | — | US | disclosed |
| US-20140336390-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2014-11-13 | — | — | US | disclosed |
| US-20140336390-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2014-11-13 | — | — | US | disclosed |
| US-20140336390-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2014-11-13 | — | — | US | disclosed |
| US-8445696-B2 | Synthetic methods for spiro-oxindole compounds | XENON PHARMACEUTICALS INC. (CA) | 2013-05-21 | — | — | US | disclosed |
| US-20130072686-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2013-03-21 | — | — | US | disclosed |
| US-20130072686-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2013-03-21 | — | — | US | disclosed |
| US-20130072686-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2013-03-21 | — | — | US | disclosed |
| EP-2488531-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | Xenon Pharmaceuticals Inc. (CA) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011047174-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2011-04-21 | — | — | WO | disclosed |
| WO-2011047174-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2011-04-21 | — | — | WO | disclosed |
| US-20110087027-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2011-04-14 | — | — | US | disclosed |
| US-20110087027-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2011-04-14 | — | — | US | disclosed |
| US-20110087027-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2011-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110087027-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | TRPV1, TRPV5, TRPV3 | KMT2A 3185/4885MEN1 2759/4885POLB 4753/4885 |
| US-20130072686-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | TRPV1, TRPV5, TRPV3 | KMT2A 3185/4885MEN1 2759/4885POLB 4753/4885 |
| US-20160326184-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | TRPV1, TRPV5, TRPV3 | KMT2A 3185/4885MEN1 2759/4885POLB 4753/4885 |
| US-20140336390-A1 | SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS | TRPV1, TRPV5, TRPV3 | KMT2A 3185/4885MEN1 2759/4885POLB 4753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.