Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HCAR3 | P49019 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31083656 | 0.89 | KMT2A (0.46) | KMT2AHCAR3ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3491006 | 0.84 | KMT2A (0.59) | KMT2AHCAR3ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9463826 | 0.83 | HCAR3 (0.59) | KMT2AHCAR3ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4784927 | 0.80 | KMT2A (0.52) | KMT2AHCAR3ALDH1A1MAPTKDM4E | |
| SCHEMBL1136193 | 0.79 | HCAR3 (0.64) | HCAR3ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL3054248 | 0.79 | KMT2A (0.50) | KMT2AHCAR3ALDH1A1MAPTLMNA | |
| SCHEMBL21624300 | 0.79 | MAPT (0.61) | KMT2AMAPTLMNAMAPK1 | |
| SCHEMBL1135955 | 0.78 | ATM (0.44) | KMT2AHCAR3ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL16540700 | 0.77 | ATM (0.49) | HCAR3MAPTLMNAKDM4EATM | |
| SCHEMBL5740839 | 0.77 | CYP1A2 (0.43) | KMT2AALDH1A1MAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008071981-A1 | PIPERIDINES FOR THE TREATMENT OF BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2008-06-19 | — | — | WO | disclosed |