Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | PRSS12 | P56730 | 7/20 | 0.52 |
| ▸ | FASN | P49327 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14209232 | 0.92 | MEN1 (0.54) | MEN1KMT2ASMN1; SMN2LMNAPRSS12 | |
| SCHEMBL4737601 | 0.90 | FASN (0.59) | MEN1KMT2ASMN1; SMN2LMNAPRSS12 | |
| SCHEMBL4784366 | 0.90 | FASN (0.49) | MEN1KMT2ASMN1; SMN2LMNAPRSS12 | |
| SCHEMBL4731259 | 0.78 | SMN1; SMN2 (0.54) | MEN1KMT2ASMN1; SMN2LMNAPRSS12 | |
| SCHEMBL16799516 | 0.77 | FASN (0.56) | FASN | |
| SCHEMBL4737156 | 0.76 | FASN (0.72) | MEN1KMT2APRSS12FASN | |
| SCHEMBL4732268 | 0.76 | FASN (0.59) | MEN1KMT2ASMN1; SMN2FASNALDH1A1 | |
| SCHEMBL4731357 | 0.76 | CA12 (0.61) | MEN1KMT2ASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL4731899 | 0.73 | SMN1; SMN2 (0.47) | MEN1KMT2ASMN1; SMN2LMNAPRSS12 | |
| SCHEMBL5909349 | 0.72 | MEN1 (0.65) | MEN1KMT2ASMN1; SMN2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008059214-A1 | BISAMLDE DERIVATIVES AND USE THEREOF AS FATTY ACID SYNTHASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-22 | — | — | WO | disclosed |