Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.80 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.80 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.80 |
| ▸ | EGFR | P00533 | 3/20 | 0.80 |
| ▸ | CDK2 | P24941 | 2/20 | 0.80 |
| ▸ | JAK2 | O60674 | 1/20 | 0.80 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.80 |
| ▸ | ZAP70 | P43403 | 7/20 | 0.70 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.70 |
| ▸ | PRKCG | P05129 | 3/20 | 0.70 |
| ▸ | PRKCB | P05771 | 3/20 | 0.70 |
| ▸ | LCK | P06239 | 3/20 | 0.70 |
| ▸ | PRKCA | P17252 | 3/20 | 0.70 |
| ▸ | PRKCH | P24723 | 3/20 | 0.70 |
| ▸ | PRKCI | P41743 | 3/20 | 0.70 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.70 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.70 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.70 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.70 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979315 | 0.89 | CDK2 (0.79) | PIK3CAPIK3CGPIK3CBEGFRCDK2 | |
| SCHEMBL6978697 | 0.89 | CDK2 (0.78) | PIK3CAPIK3CGPIK3CBEGFRCDK2 | |
| SCHEMBL6977451 | 0.89 | CDK2 (0.78) | PIK3CAPIK3CGPIK3CBEGFRCDK2 | |
| SCHEMBL6972462 | 0.89 | PIK3CG (0.78) | PIK3CAPIK3CGPIK3CBEGFRCDK2 | |
| SCHEMBL6971022 | 0.88 | CDK2 (0.70) | PIK3CAPIK3CGPIK3CBEGFRCDK2 | |
| Dimethylamine SCHEMBL6970249 | 0.88 | CDK2 (0.70) | PIK3CAPIK3CGPIK3CBEGFRCDK2 | |
| SCHEMBL6977323 | 0.88 | CDK2 (0.77) | PIK3CAPIK3CGPIK3CBEGFRCDK2 | |
| SCHEMBL6974310 | 0.88 | ZAP70 (0.80) | PIK3CAPIK3CGPIK3CBEGFRCDK2 | |
| SCHEMBL6976607 | 0.88 | ZAP70 (0.69) | PIK3CAPIK3CGPIK3CBEGFRCDK2 | |
| SCHEMBL6977138 | 0.86 | ZAP70 (0.73) | PIK3CAPIK3CGPIK3CBEGFRCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080153822-A1 | Methods of treating pain | INGENIUM PHARMACEUTICALS GMBH (DE) | 2008-06-26 | — | — | US | disclosed |
| WO-2008065155-A1 | CDK INHIBITORS FOR TREATING PAIN | INGENIUM PHARMACEUTICALS GMBH (DE) | 2008-06-05 | — | — | WO | disclosed |
| US-20070021419-A1 | 2-Aminophenyl-4-phenylpyrimidines as kinase inhibitors | CYCLACEL LIMITED (GB) | 2007-01-25 | — | — | US | disclosed |
| EP-1648875-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | Cyclacel Limited (GB) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005012262-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | CYCLACEL LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |
| EP-0862560-B1 | SUBSTITUTED 2-ANILINOPYRIMIDINES USEFUL AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-04-02 | — | — | EP | disclosed |
| US-6235746-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATIVE AGENT | CELLTECH THERAPEUTICS, LIMITED (GB) | 2001-05-22 | — | — | US | disclosed |
| US-5958935-A | Substituted 2-anilinopyrimidines useful as protein kinase inhibitors | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021419-A1 | 2-Aminophenyl-4-phenylpyrimidines as kinase inhibitors | GRK3, NCOR1, GRM3 | PIK3CA 780/4885PIK3CG 1548/4885PIK3CB 1461/4885 |
| US-20080153822-A1 | Methods of treating pain | OPRL1, ACHE, OPRK1 | PIK3CA 4390/4885PIK3CG 4311/4885PIK3CB 4543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.