Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.39 |
| ▸ | WNT3 | P56703 | 1/20 | 0.39 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732292 | 1.00 | SFRP1 (0.39) | SFRP1WNT3PFKFB3NR1H2ACLY | |
| SCHEMBL4733218 | 1.00 | SFRP1 (0.39) | SFRP1WNT3PFKFB3NR1H2ACLY | |
| SCHEMBL4784546 | 0.87 | NR1H2 (0.46) | SFRP1WNT3PFKFB3NR1H2ADRA2A | |
| SCHEMBL4731532 | 0.86 | NR1H2 (0.43) | SFRP1WNT3NR1H2SLC22A12TP53 | |
| SCHEMBL4783662 | 0.82 | CA1 (0.49) | SFRP1WNT3PFKFB3NR1H2ADRA2A | |
| SCHEMBL4783169 | 0.82 | CA1 (0.49) | SFRP1WNT3PFKFB3NR1H2ADRA2A | |
| SCHEMBL4783899 | 0.82 | CA1 (0.49) | SFRP1WNT3PFKFB3NR1H2ADRA2A | |
| SCHEMBL4794680 | 0.80 | NR1H2 (0.46) | SFRP1WNT3PFKFB3NR1H2ADRA2A | |
| SCHEMBL2372639 | 0.78 | CNR2 (0.48) | SFRP1WNT3PFKFB3ADRA2ANPY5R | |
| SCHEMBL4782680 | 0.76 | NR1H2 (0.39) | SFRP1WNT3PFKFB3NR1H2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |