Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | PNMT | P11086 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.40 |
| ▸ | WNT3 | P56703 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783662 | 1.00 | CA1 (0.49) | CA1CA2PNMTHDAC8NR1H2 | |
| SCHEMBL4783169 | 1.00 | CA1 (0.49) | CA1CA2PNMTHDAC8NR1H2 | |
| SCHEMBL4784546 | 0.92 | NR1H2 (0.46) | CA1CA2NR1H2SFRP1WNT3 | |
| SCHEMBL4732746 | 0.86 | CA1 (0.56) | CA1CA2PNMTHDAC8NR1H2 | |
| SCHEMBL4794680 | 0.84 | NR1H2 (0.46) | PNMTHDAC8NR1H2SFRP1WNT3 | |
| SCHEMBL2372639 | 0.83 | CNR2 (0.48) | SFRP1WNT3ADRA2ANPY5RMCHR1 | |
| SCHEMBL4733218 | 0.82 | SFRP1 (0.39) | NR1H2SFRP1WNT3ADRA2ANPY5R | |
| SCHEMBL4732292 | 0.82 | SFRP1 (0.39) | NR1H2SFRP1WNT3ADRA2ANPY5R | |
| SCHEMBL4733090 | 0.82 | SFRP1 (0.39) | NR1H2SFRP1WNT3ADRA2ANPY5R | |
| SCHEMBL4780533 | 0.81 | NR1H2 (0.43) | HDAC8NR1H2SFRP1WNT3ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |