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Sugi Predict / Compounds / SCHEMBL4733150

SCHEMBL4733150

SCHEMBL4733150

O=C(c1ccc(Cl)nc1)N1CCC(NS(=O)(=O)c2ccc(-c3ccccc3OC(F)(F)F)cc2C(F)(F)F)CC1

nearest known ligand 0.63

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ SFRP1 Q8N474 16/20 0.63
▸ EPHX2 P34913 1/20 0.49
▸ WNT3 P56703 2/20 0.41
▸ CTSS P25774 1/20 0.41
▸ PKLR P30613 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4738622 0.91 SFRP1 (0.61) SFRP1EPHX2WNT3CTSS
SCHEMBL4735625 0.91 SFRP1 (0.66) SFRP1EPHX2WNT3
SCHEMBL4737870 0.90 SFRP1 (0.65) SFRP1EPHX2WNT3
SCHEMBL4733287 0.90 SFRP1 (0.60) SFRP1EPHX2WNT3
SCHEMBL4735101 0.89 SFRP1 (0.66) SFRP1EPHX2WNT3
SCHEMBL4733575 0.88 SFRP1 (0.71) SFRP1EPHX2WNT3
SCHEMBL4734144 0.88 SFRP1 (0.63) SFRP1EPHX2WNT3
SCHEMBL4731662 0.88 SFRP1 (0.63) SFRP1EPHX2WNT3
SCHEMBL4802692 0.88 SFRP1 (0.63) SFRP1EPHX2WNT3
SCHEMBL4734932 0.87 SFRP1 (0.62) SFRP1EPHX2WNT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008061016-A1 N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 WYETH (US) 2008-05-22 — — WO claimed
WO-2008061016-A1 N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 WYETH (US) 2008-05-22 — — WO disclosed