Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.54 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.54 |
| ▸ | MLKL | Q8NB16 | 2/20 | 0.54 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.52 |
| ▸ | TNNI3K | Q59H18 | 5/20 | 0.52 |
| ▸ | BRAF | P15056 | 3/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17979820 | 0.87 | KDR (0.50) | KDRRIPK1MLKLRIPK3BRAF | |
| SCHEMBL17979914 | 0.84 | KDR (0.49) | KDRRIPK1MLKLRIPK3BRAF | |
| SCHEMBL17260979 | 0.81 | KDR (0.65) | KDRRIPK1MLKLRIPK3MEN1 | |
| SCHEMBL23065786 | 0.80 | KMT2A (0.62) | KDRRIPK1MEN1KMT2AMAPT | |
| SCHEMBL19899212 | 0.79 | KDR (0.59) | KDRRIPK1MLKLRIPK3MAPK14 | |
| SCHEMBL18024707 | 0.78 | KDR (0.58) | KDRRIPK1MLKLRIPK3MAPK14 | |
| SCHEMBL4733237 | 0.78 | KMT2A (0.54) | KDRRIPK1MEN1KMT2AMAPT | |
| SCHEMBL4808894 | 0.77 | POLB (0.47) | KDRMEN1KMT2AMAPTHTT | |
| SCHEMBL4735597 | 0.77 | KDR (0.45) | KDRMAPTRAB9AAURKANPC1 | |
| SCHEMBL4731171 | 0.76 | KDR (0.61) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060866-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-05-22 | — | — | WO | disclosed |