Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 9/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.52 |
| ▸ | TNNI3K | Q59H18 | 7/20 | 0.52 |
| ▸ | BRAF | P15056 | 6/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 2/20 | 0.50 |
| ▸ | CDK7 | P50613 | 1/20 | 0.50 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23065786 | 0.81 | KMT2A (0.62) | KMT2AMAPTMEN1HTTRAB9A | |
| SCHEMBL4733239 | 0.78 | KDR (0.54) | KMT2AMAPTMEN1HTTRAB9A | |
| SCHEMBL22155019 | 0.76 | SMARCA2 (0.69) | KMT2AMAPTMEN1HTTRAB9A | |
| SCHEMBL14601707 | 0.75 | KMT2A (0.77) | KMT2AMAPTMEN1HTTRAB9A | |
| SCHEMBL30101230 | 0.74 | KMT2A (0.90) | KMT2AMAPTMEN1HTTRAB9A | |
| SCHEMBL5597699 | 0.74 | KMT2A (0.90) | KMT2AMAPTMEN1HTTRAB9A | |
| SCHEMBL16654502 | 0.72 | MAOA (0.56) | KMT2AMAPTMEN1RAB9AJAK2 | |
| SCHEMBL17609423 | 0.72 | MAPT (1.00) | KMT2AMAPTMEN1HTTRAB9A | |
| SCHEMBL30069239 | 0.72 | MAPT (1.00) | KMT2AMAPTMEN1HTTRAB9A | |
| SCHEMBL3260524 | 0.72 | KDR (0.76) | KMT2AMAPTMEN1HTTKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060866-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-05-22 | — | — | WO | disclosed |