SCHEMBL4733547

SCHEMBL4733547

COc1ccc([SiH2]CC(Cl)Cl)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.46
CA2 P00918 3/20 0.46
CA7 P43166 2/20 0.46
CA9 Q16790 2/20 0.46
CA12 O43570 1/20 0.46
CA14 Q9ULX7 1/20 0.46
GAA P10253 2/20 0.42
MAPT P10636 2/20 0.42
MAPK1 P28482 3/20 0.41
TDP1 Q9NUW8 3/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
KDM4E B2RXH2 1/20 0.41
NPC1 O15118 1/20 0.41
THRB P10828 1/20 0.41
RECQL P46063 1/20 0.41
RAB9A P51151 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
ALDH1A1 P00352 1/20 0.39
TSHR P16473 1/20 0.39
ACHE P22303 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL707867 0.82
SCHEMBL8428815 0.76 CA1 (0.52) CA1CA2CA7CA9CA12
SCHEMBL16577600 0.72 CA1 (0.48) CA1CA2CA7CA9CA12
SCHEMBL22472155 0.72 CA1 (0.48) CA1CA2CA7CA9CA12
SCHEMBL12894663 0.70 CA1 (0.58) CA1CA2CA7CA9CA12
SCHEMBL2103828 0.70 TSHR (0.38) MAPK1L3MBTL1KDM4ERAB9AALDH1A1
SCHEMBL6834823 0.69 CA1 (0.65) CA1CA2CA7CA9CA12
SCHEMBL10481599 0.68 ALDH1A1 (0.50) CA1CA2CA7CA9CA12
1,4-Dimethoxybenzene SCHEMBL21802643 0.68 CA1 (1.00) CA1CA2CA7CA9CA12
1,4-Dimethoxybenzene SCHEMBL8489 0.68 CA1 (1.00) CA1CA2CA7CA9CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008063134-A1 METHOD OF PRODUCING A PATTERN OF DISCRIMINATIVE WETTABILITY AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2008-05-29 WO disclosed