Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28587931 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2PPARGL3MBTL1CA1CA2 | |
| SCHEMBL11477738 | 0.76 | SMN1; SMN2 (0.55) | SMN1; SMN2PPARGL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL28612103 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2L3MBTL1CA1CA2CA4 | |
| SCHEMBL9363341 | 0.74 | OPRM1 (0.37) | ALDH1A1HPGDKDM4EKMT2AMAPT | |
| SCHEMBL10341539 | 0.73 | SMN1; SMN2 (0.47) | SMN1; SMN2PPARGL3MBTL1CA1CA2 | |
| SCHEMBL13988029 | 0.72 | KDM4E (0.45) | L3MBTL1CA1CA2CA7CA9 | |
| SCHEMBL9937345 | 0.72 | OPRM1 (0.39) | ALDH1A1HPGDKDM4EKMT2AMAPT | |
| SCHEMBL27188920 | 0.72 | BRD4 (0.43) | SMN1; SMN2L3MBTL1ALDH1A1HPGDKDM4E | |
| SCHEMBL27188925 | 0.71 | SMN1; SMN2 (0.45) | SMN1; SMN2L3MBTL1CA1CA2CA4 | |
| SCHEMBL14638438 | 0.71 | APP (0.49) | SMN1; SMN2PPARGL3MBTL1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008057309-A2 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2008-05-15 | — | — | WO | disclosed |
| WO-2008057309-A2 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2008-05-15 | — | — | WO | disclosed |
| US-20070293706-A1 | Synthesis Of 1,5-Disubstituted-2-Hydroxy-Gibbatetraen-6-Ones | MERCK & CO., INC. | 2007-12-20 | — | — | US | disclosed |
| US-20070293706-A1 | Synthesis Of 1,5-Disubstituted-2-Hydroxy-Gibbatetraen-6-Ones | MERCK & CO., INC. | 2007-12-20 | — | — | US | disclosed |
| US-20070293706-A1 | Synthesis Of 1,5-Disubstituted-2-Hydroxy-Gibbatetraen-6-Ones | MERCK & CO., INC. | 2007-12-20 | — | — | US | disclosed |
| EP-1819656-A2 | SYNTHESIS OF 1,5-DISTRIBUTED-2-HYDROXY-GIBBATETRAEN-6-ONES | Merck & Co., Inc. (US) | 2007-08-22 | — | — | EP | disclosed |
| EP-1809594-A1 | ESTROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2007-07-25 | — | — | EP | disclosed |
| US-7151196-B2 | Estrogen receptor modulators | MERCK & CO., INC. (US) | 2006-12-19 | — | — | US | disclosed |
| WO-2006050399-A2 | SYNTHESIS OF 1,5-DISUBSTITUTED-2-HYDROXY-GIBBATETRAEN-6-ONES | MERCK & CO., INC. (US) | 2006-05-11 | — | — | WO | disclosed |
| WO-2006050402-A1 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2006-05-11 | — | — | WO | disclosed |
| US-20060094779-A1 | Estrogen receptor modulators | MERCK SHARP & DOHME CORP. | 2006-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094779-A1 | Estrogen receptor modulators | GPER1, ESR2, ESRRA | SMN1; SMN2 1597/4885PPARG 222/4885L3MBTL1 3310/4885 |
| US-20070293706-A1 | Synthesis Of 1,5-Disubstituted-2-Hydroxy-Gibbatetraen-6-Ones | ESR1, GPER1, CYP19A1 | SMN1; SMN2 4865/4885PPARG 1326/4885L3MBTL1 3129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.