Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4731773 | 0.87 | PARG (0.37) | SMN1; SMN2LMNAMEN1KMT2ATDP1 | |
| SCHEMBL4734759 | 0.86 | MEN1 (0.45) | ALDH1A1SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL4734712 | 0.84 | POLB (0.46) | ALDH1A1SMN1; SMN2POLBNPSR1SFRP1 | |
| SCHEMBL4732674 | 0.83 | ALOX5AP (0.34) | KDM4ERXFP1POLBFEN1 | |
| SCHEMBL4731973 | 0.82 | HPGD (0.39) | ALDH1A1PDK1PDK2PDK3PDK4 | |
| SCHEMBL4730924 | 0.81 | ALDH1A1 (0.32) | ALDH1A1MAPK1TDP1 | |
| SCHEMBL4733963 | 0.79 | CNR2 (0.38) | LMNAMEN1KMT2ANPSR1 | |
| SCHEMBL4731366 | 0.79 | HTT (0.36) | LMNAMEN1KMT2AMAPTFEN1 | |
| SCHEMBL4731370 | 0.79 | HTT (0.36) | LMNAMEN1KMT2AMAPTFEN1 | |
| SCHEMBL4734862 | 0.79 | MEN1 (0.41) | MEN1KMT2ASFRP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |