Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BRD2 | P25440 | 1/20 | 0.36 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734759 | 0.90 | MEN1 (0.45) | POLBALDH1A1TSHRSMN1; SMN2HTT | |
| SCHEMBL4731926 | 0.89 | POLB (0.47) | POLBALDH1A1TSHRSMN1; SMN2HTT | |
| SCHEMBL4731748 | 0.86 | POLB (0.45) | POLBALDH1A1TSHRSMN1; SMN2HTT | |
| SCHEMBL4733147 | 0.85 | POLB (0.44) | POLBALDH1A1TSHRSMN1; SMN2HTT | |
| SCHEMBL4733900 | 0.84 | ALDH1A1 (0.41) | POLBALDH1A1SMN1; SMN2SFRP1NPSR1 | |
| SCHEMBL4731445 | 0.84 | MEN1 (0.46) | PRMT5WDR77 | |
| SCHEMBL4733942 | 0.79 | POLB (0.48) | POLBALDH1A1TSHRSMN1; SMN2HTT | |
| SCHEMBL4734599 | 0.79 | POLB (0.48) | POLBALDH1A1TSHRSMN1; SMN2HTT | |
| SCHEMBL4734109 | 0.76 | MEN1 (0.43) | POLBALDH1A1TSHRSMN1; SMN2HTT | |
| SCHEMBL4734886 | 0.76 | POLB (0.45) | POLBALDH1A1TSHRSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |