Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 10/20 | 0.64 |
| ▸ | CA1 | P00915 | 9/20 | 0.64 |
| ▸ | CA9 | Q16790 | 9/20 | 0.64 |
| ▸ | CA12 | O43570 | 8/20 | 0.64 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.58 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.56 |
| ▸ | IKBKB | O14920 | 1/20 | 0.56 |
| ▸ | CA4 | P22748 | 2/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.56 |
| ▸ | CA3 | P07451 | 1/20 | 0.56 |
| ▸ | CA6 | P23280 | 1/20 | 0.56 |
| ▸ | CA5A | P35218 | 1/20 | 0.56 |
| ▸ | CA7 | P43166 | 1/20 | 0.56 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.56 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.56 |
| ▸ | BRD4 | O60885 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.53 |
| ▸ | TTK | P33981 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2311184 | 0.91 | LRRK2 (0.56) | CA2CA1CA9CA12CA13 | |
| SCHEMBL1926937 | 0.86 | CA2 (0.67) | CA2CA1CA9CA12CA13 | |
| SCHEMBL2308295 | 0.85 | CA2 (0.56) | CA2CA1CA9CA12CA13 | |
| SCHEMBL14161390 | 0.84 | CA1 (0.55) | CA2CA1CA9CA12CA13 | |
| SCHEMBL962658 | 0.84 | CA1 (0.67) | CA2CA1CA9CA12CA13 | |
| SCHEMBL4733933 | 0.82 | CA2 (0.61) | CA2CA1CA9CA12CA13 | |
| SCHEMBL4575215 | 0.82 | CA2 (0.79) | CA2CA1CA9CA12CA13 | |
| SCHEMBL28032548 | 0.81 | CA2 (0.73) | CA2CA1CA9CA12CA13 | |
| SCHEMBL30434205 | 0.81 | CA2 (0.64) | CA2CA1CA9CA12CA13 | |
| SCHEMBL5305260 | 0.81 | TSHR (0.56) | CA2CA1CA9CA12LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101970406-A | Novel triaryl derivatives useful as modulators of nicotinic acetylcholine receptors | NEUROSEARCH AS | 2011-02-09 | — | — | CN | claimed |
| CN-101970406-A | Novel triaryl derivatives useful as modulators of nicotinic acetylcholine receptors | NEUROSEARCH AS | 2011-02-09 | — | — | CN | disclosed |
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |