Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 9/20 | 0.61 |
| ▸ | CA9 | Q16790 | 7/20 | 0.61 |
| ▸ | CA1 | P00915 | 7/20 | 0.61 |
| ▸ | CA12 | O43570 | 6/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 2/20 | 0.52 |
| ▸ | CA3 | P07451 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.52 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.52 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30434205 | 0.98 | CA2 (0.64) | CA2CA9CA1CA12PTGS2 | |
| SCHEMBL2311184 | 0.93 | LRRK2 (0.56) | CA2CA9CA1CA12PTGS2 | |
| SCHEMBL30221774 | 0.90 | CA12 (0.55) | CA2CA9CA1CA12PTGS2 | |
| SCHEMBL30269780 | 0.86 | CA2 (0.59) | CA2CA9CA1CA12PTGS2 | |
| SCHEMBL6794823 | 0.85 | CA1 (0.66) | CA2CA9CA1CA12PTGS2 | |
| SCHEMBL30301831 | 0.85 | CA12 (0.57) | CA2CA9CA1CA12PTGS2 | |
| SCHEMBL2309450 | 0.84 | CA2 (0.64) | CA2CA9CA1CA12PTGS2 | |
| SCHEMBL11045136 | 0.83 | PTGS2 (0.53) | CA2CA9CA1CA12PTGS2 | |
| SCHEMBL4575215 | 0.83 | CA2 (0.79) | CA2CA9CA1CA12PTGS2 | |
| SCHEMBL2309051 | 0.83 | CA2 (0.48) | CA2CA9CA1CA12PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061016-A1 | N-SUBSTITUTED PIPERIDINYL 4 -ARYLSULFONAMIDES AS MODULATORS OF THE SECRETED FRIZZLED RELATED PROTEIN- 1 | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| US-6376523-B1 | HYPOTENSIVE AGENTS; ANTIINFLAMMATORY AGENTS; ENDOGENOUS VASOCONSTRUCTION PEPTIDE | TEXAS BIOTECHNOLOGY CORPORATION | 2002-04-23 | — | — | US | disclosed |