Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.36 |
| ▸ | MTOR | P42345 | 3/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PIK3C2G | O75747 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4733956 | 1.00 | PIK3CD (0.36) | PIK3CDPIK3CBMTORPIK3CGPIK3C3 | |
| SCHEMBL4736205 | 0.88 | HTT (0.35) | HTTBRD4BRD2BRD3TP53 | |
| SCHEMBL4737035 | 0.88 | BRD4 (0.43) | HTTBRD4BRD2BRD3ALOX5AP | |
| SCHEMBL4919374 | 0.87 | HTT (0.36) | PIK3CDPIK3CBMTORPIK3CGPIK3C3 | |
| SCHEMBL4731366 | 0.87 | HTT (0.36) | PIK3CDPIK3CBMTORPIK3CGPIK3C3 | |
| SCHEMBL4731370 | 0.87 | HTT (0.36) | PIK3CDPIK3CBMTORPIK3CGPIK3C3 | |
| SCHEMBL4801590 | 0.86 | HTT (0.38) | PIK3CDPIK3CBMTORPIK3CGPIK3C3 | |
| SCHEMBL4730981 | 0.83 | SFRP1 (0.46) | MEN1KMT2A | |
| SCHEMBL4733321 | 0.82 | CCR8 (0.47) | BRD4 | |
| SCHEMBL4733258 | 0.80 | SFRP1 (0.51) | L3MBTL1MEN1KMT2ALMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |