Sugi Predict

Sugi Predict / Compounds / SCHEMBL4733258

SCHEMBL4733258

SCHEMBL4733258

Cc1cc2c(cc1S(=O)(=O)NC1CCN(S(=O)(=O)c3ccc(C(=O)O)cc3)CC1)S(=O)(=O)c1ccccc1C2(C)C

nearest known ligand 0.51

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ SFRP1 Q8N474 4/20 0.51
▸ MEN1 O00255 5/20 0.42
▸ KMT2A Q03164 5/20 0.42
▸ ALDH1A1 P00352 3/20 0.42
▸ LMNA P02545 1/20 0.39
▸ EPHX2 P34913 2/20 0.39
▸ GAA P10253 1/20 0.39
▸ CYP26A1 O43174 1/20 0.38
▸ POLB P06746 1/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4733261 0.92 SFRP1 (0.51) SFRP1MEN1KMT2AALDH1A1LMNA
SCHEMBL4730237 0.85 MEN1 (0.39) SFRP1MEN1KMT2A
SCHEMBL4730981 0.82 SFRP1 (0.46) SFRP1MEN1KMT2AALDH1A1CYP26A1
SCHEMBL4730491 0.82 SFRP1 (0.50) SFRP1MEN1KMT2AALDH1A1EPHX2
SCHEMBL4733956 0.80 PIK3CD (0.36) MEN1KMT2ALMNAGAAL3MBTL1
SCHEMBL4733321 0.79 CCR8 (0.47) SFRP1EPHX2
SCHEMBL4732159 0.79 SFRP1 (0.49) SFRP1
SCHEMBL4736205 0.78 HTT (0.35) MEN1KMT2ALMNAGAA
SCHEMBL4737035 0.78 BRD4 (0.43) SFRP1MEN1KMT2ALMNAGAA
SCHEMBL4730240 0.76 CCR8 (0.39) SFRP1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008061029-A1 ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE WYETH (US) 2008-05-22 — — WO disclosed