Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | ME2 | P23368 | 1/20 | 0.41 |
| ▸ | ME1 | P48163 | 1/20 | 0.41 |
| ▸ | ME3 | Q16798 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.41 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.40 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.40 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2847261 | 0.99 | DPP4 (0.47) | DPP4HTR2CHTR2BPOLBDPP7 | |
| SCHEMBL2548946 | 0.84 | ALDH1A1 (0.48) | DPP4POLBDPP7RAB9AKDM4E | |
| SCHEMBL8665194 | 0.82 | L3MBTL1 (0.48) | DPP4POLBKDM4ESIGMAR1ALDH1A1 | |
| SCHEMBL8908929 | 0.80 | POLB (0.67) | DPP4POLBSMN1; SMN2ALDH1A1ME2 | |
| Hydrochloric Acid SCHEMBL2848820 | 0.79 | KDM4E (0.42) | DPP4HTR2CHTR2BPOLBRAB9A | |
| SCHEMBL4680752 | 0.79 | ALDH1A1 (0.53) | HTR2CHTR2BRAB9AALDH1A1PARP1 | |
| SCHEMBL4684629 | 0.79 | HTR2C (0.43) | DPP4HTR2CHTR2BDPP7KDM4E | |
| SCHEMBL3921321 | 0.79 | L3MBTL1 (0.56) | DPP4HTR2CPOLBDPP7SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL21681605 | 0.78 | POLB (0.65) | DPP4POLBSMN1; SMN2ALDH1A1ME2 | |
| Hydrochloric Acid SCHEMBL17560387 | 0.78 | HTR2C (0.69) | DPP4HTR2CHTR2BPOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054748-A2 | INDAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-05-08 | — | — | WO | disclosed |