Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 6/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736099 | 1.00 | KDM1A (0.42) | KDM1AMAOBSIGMAR1TSHRALDH1A1 | |
| SCHEMBL27889440 | 0.80 | KDM1A (0.46) | KDM1AMAOBSIGMAR1TSHRALDH1A1 | |
| SCHEMBL29501701 | 0.79 | SIGMAR1 (0.43) | KDM1AMAOBSIGMAR1TSHRALDH1A1 | |
| SCHEMBL17603684 | 0.78 | KDM1A (0.47) | KDM1AMAOBSIGMAR1TSHRALDH1A1 | |
| SCHEMBL742365 | 0.77 | KDM1A (0.46) | KDM1AMAOBSIGMAR1TSHRALDH1A1 | |
| SCHEMBL28922175 | 0.76 | SIGMAR1 (0.41) | KDM1AMAOBSIGMAR1ALDH1A1TP53 | |
| SCHEMBL19130507 | 0.76 | SIGMAR1 (0.41) | KDM1AMAOBSIGMAR1TSHRALDH1A1 | |
| SCHEMBL17603661 | 0.75 | KDM1A (0.44) | KDM1AMAOBSIGMAR1TSHRALDH1A1 | |
| SCHEMBL9748439 | 0.75 | SIGMAR1 (0.40) | KDM1AMAOBSIGMAR1TSHRALDH1A1 | |
| SCHEMBL9280563 | 0.74 | SIGMAR1 (0.44) | KDM1AMAOBSIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008071765-A1 | PHARMACEUTICALLY ACTIVE SPIRO-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | NYCOMED GMBH (DE) | 2008-06-19 | — | — | WO | disclosed |