Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18059962 | 1.00 | MEN1 (0.41) | MEN1KMT2ATSHRMAPK1THRB | |
| SCHEMBL25289772 | 0.96 | TSHR (0.35) | MEN1KMT2ATSHRMAPK1ALDH1A1 | |
| SCHEMBL22770977 | 0.85 | NOS3 (0.33) | NOS3NOS1NOS2 | |
| SCHEMBL1134009 | 0.85 | NOS3 (0.33) | NOS3NOS1NOS2 | |
| SCHEMBL17841798 | 0.85 | NOS3 (0.33) | NOS3NOS1NOS2 | |
| SCHEMBL23754647 | 0.84 | NOS3 (0.33) | NOS3NOS1NOS2 | |
| SCHEMBL22588782 | 0.81 | HSD17B10 (0.43) | MEN1KMT2AMAPK1HTTMAPT | |
| SCHEMBL15020184 | 0.81 | — | — | |
| SCHEMBL31577906 | 0.77 | MEN1 (0.37) | MEN1KMT2ATSHRMAPK1THRB | |
| SCHEMBL7626489 | 0.76 | TSHR (0.31) | TSHRMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3757093-A1 | DIHYDROPYRIDAZINE-3,5-DIONE DERIVATIVE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2020-12-30 | — | — | EP | disclosed |
| WO-2008075955-A2 | PROCESS FOR THE PREPARATION OF 1,4,5-TRISUBSTITUTED TRIAZOLES AND 3,4,5-TRISUBSTITUTED TRIAZOLES | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2008-06-26 | — | — | WO | disclosed |