Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | LIMK2 | P53671 | 4/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.38 |
| ▸ | AKT1 | P31749 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | AKT1S1 | Q96B36 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3032138 | 0.86 | AKT1 (0.43) | MEN1KMT2ACSF1RAKT1KDM4E | |
| SCHEMBL473291 | 0.82 | CHKA (0.46) | MEN1KMT2ALIMK2RPS6KB1AKT1 | |
| SCHEMBL10159430 | 0.81 | CSF1R (0.43) | MEN1KMT2ACSF1RAKT1LMNA | |
| SCHEMBL4923498 | 0.81 | LIMK2 (0.41) | LIMK2RPS6KB1AKT1AKT1S1 | |
| SCHEMBL473448 | 0.80 | ALDH1A1 (0.50) | MEN1KMT2ALMNAKDM4EALDH1A1 | |
| SCHEMBL473341 | 0.79 | PDE10A (0.45) | MEN1KMT2ARAB9ACSF1RRPS6KB1 | |
| SCHEMBL473395 | 0.79 | RECQL (0.54) | MEN1KMT2ALMNAKDM4EALDH1A1 | |
| SCHEMBL473325 | 0.79 | LMNA (0.56) | MEN1KMT2ACSF1RRPS6KB1AKT1 | |
| SCHEMBL10158974 | 0.79 | CSF1R (0.39) | MEN1KMT2ARAB9ACSF1RRPS6KB1 | |
| SCHEMBL1795146 | 0.79 | TTR (0.53) | LIMK2RPS6KB1AKT1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848719-B1 | [1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YL]-PIPERIDINE OR -PIPERAZINE COMPOUNDS AS SERINE-THREONINE KINASE MODULATORS (P70S6K, ATK1 AND ATK2) FOR THE TREATMENT OF IMMUNOLOGICAL, INFLAMMATORY AND PROLIFERATIVE DISEASES | EXELIXIS INC (US) | 2012-02-01 | — | — | EP | disclosed |