Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.37 |
| ▸ | GPR3 | P46089 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19319666 | 0.90 | KDM4E (0.37) | KDM4EALDH1A1HSD17B10LMNATP53 | |
| SCHEMBL2756510 | 0.88 | CA1 (0.37) | KDM4ELMNAKMT2AMEN1TDP1 | |
| SCHEMBL21390569 | 0.85 | KMT2A (0.48) | KDM4ELMNATP53KMT2AMEN1 | |
| SCHEMBL30193036 | 0.85 | KMT2A (0.48) | KDM4ELMNATP53KMT2AMEN1 | |
| SCHEMBL19319663 | 0.81 | KMT2A (0.36) | KDM4EKMT2AMEN1NOX1GPR3 | |
| SCHEMBL4731718 | 0.79 | LMNA (0.38) | KDM4EALDH1A1HSD17B10LMNATP53 | |
| SCHEMBL19319631 | 0.79 | LMNA (0.33) | LMNATP53KMT2AMEN1NOX1 | |
| SCHEMBL9980159 | 0.79 | HTR2A (0.32) | HSD17B10LMNA | |
| SCHEMBL21364171 | 0.78 | PDK2 (0.44) | KDM4EALDH1A1HSD17B10LMNATP53 | |
| SCHEMBL21364087 | 0.78 | PDK2 (0.44) | KDM4EALDH1A1HSD17B10LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |