Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.78 |
| ▸ | MEN1 | O00255 | 5/20 | 0.78 |
| ▸ | HPGD | P15428 | 3/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.78 |
| ▸ | HTT | P42858 | 1/20 | 0.78 |
| ▸ | ATM | Q13315 | 1/20 | 0.78 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2760354 | 0.88 | KMT2A (0.73) | KMT2AALDH1A1MEN1HPGDKDM4E | |
| SCHEMBL3749553 | 0.81 | ALDH1A1 (1.00) | KMT2AALDH1A1MEN1HPGDKDM4E | |
| SCHEMBL5644218 | 0.81 | ALDH1A1 (0.73) | KMT2AALDH1A1MEN1HPGDKDM4E | |
| SCHEMBL5362218 | 0.81 | HPGD (1.00) | KMT2AALDH1A1MEN1HPGDKDM4E | |
| SCHEMBL7136366 | 0.81 | ALDH1A1 (1.00) | KMT2AALDH1A1MEN1HPGDKDM4E | |
| SCHEMBL563504 | 0.81 | KMT2A (0.68) | KMT2AALDH1A1MEN1HPGDKDM4E | |
| SCHEMBL5640862 | 0.81 | KMT2A (0.63) | KMT2AALDH1A1MEN1HPGDKDM4E | |
| SCHEMBL11707838 | 0.81 | KMT2A (0.63) | KMT2AALDH1A1MEN1HPGDKDM4E | |
| SCHEMBL11751891 | 0.81 | KMT2A (0.63) | KMT2AALDH1A1MEN1HPGDKDM4E | |
| SCHEMBL125602 | 0.80 | ALDH1A1 (0.61) | KMT2AALDH1A1MEN1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| US-4045570-A | Heterocyclic S-imino-S-oxides | CIBA-GEIGY CORPORATION (US) | 1977-08-30 | — | — | US | disclosed |
| US-4035385-A | NEUROLEPTIC AGENTS, PROPYNYLAMINE-SUBSTITUTED | HOFFMANN-LA ROCHE INC. (US) | 1977-07-12 | — | — | US | disclosed |
| US-4035386-A | NEUROLEPTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1977-07-12 | — | — | US | disclosed |
| US-4005105-A | NEUROLEPTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1977-01-25 | — | — | US | disclosed |