Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | IL1RN | P18510 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734135 | 0.94 | SFRP1 (0.50) | SFRP1KMT2AMEN1AKR1C3TSHR | |
| SCHEMBL4730846 | 0.84 | DPP4 (0.39) | SFRP1EPHX2L3MBTL1POLBSMN1; SMN2 | |
| SCHEMBL4731048 | 0.82 | SFRP1 (0.42) | SFRP1KMT2AMEN1EPHX2L3MBTL1 | |
| SCHEMBL4736144 | 0.80 | SFRP1 (0.42) | SFRP1EPHX2L3MBTL1POLBSMN1; SMN2 | |
| SCHEMBL4730501 | 0.78 | DPP4 (0.39) | SFRP1EPHX2L3MBTL1POLBSMN1; SMN2 | |
| SCHEMBL4733261 | 0.76 | SFRP1 (0.51) | SFRP1KMT2AMEN1EPHX2L3MBTL1 | |
| SCHEMBL4731040 | 0.76 | SFRP1 (0.42) | SFRP1KMT2AMEN1EPHX2L3MBTL1 | |
| SCHEMBL4734185 | 0.75 | KMT2A (0.46) | SFRP1KMT2AMEN1AKR1C3TSHR | |
| SCHEMBL4735474 | 0.75 | SFRP1 (0.72) | SFRP1KMT2AMEN1AKR1C3TSHR | |
| SCHEMBL4730880 | 0.75 | MEN1 (0.36) | SFRP1KMT2AMEN1POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |