Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 4/20 | 0.37 |
| ▸ | HTR7 | P34969 | 4/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4731040 | 0.93 | SFRP1 (0.42) | SFRP1HTR1AHTR7CCR3DRD2 | |
| SCHEMBL4736144 | 0.93 | SFRP1 (0.42) | SFRP1HTR1AHTR7DRD2HTR6 | |
| SCHEMBL4730846 | 0.89 | DPP4 (0.39) | SFRP1EPHX2DPP4KCNH2DPP7 | |
| SCHEMBL4736140 | 0.86 | SFRP1 (0.42) | SFRP1HTR1AHTR7DRD2HTR6 | |
| SCHEMBL4730501 | 0.82 | DPP4 (0.39) | SFRP1EPHX2DPP4KCNH2DPP7 | |
| SCHEMBL4734751 | 0.82 | SFRP1 (0.50) | SFRP1EPHX2ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL4730986 | 0.80 | SFRP1 (0.46) | SFRP1HTR1AHTR7ALDH1A1MEN1 | |
| SCHEMBL4734137 | 0.77 | SFRP1 (0.43) | SFRP1 | |
| SCHEMBL4734135 | 0.76 | SFRP1 (0.50) | SFRP1EPHX2ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL4735151 | 0.75 | BRD4 (0.35) | SFRP1HTR6DPP4KCNH2DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061029-A1 | ARYL SULFONAMIDE DERIVATIVES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |